All cancer patients test free of disease after going through ‘compelling’ new immunotherapy treatment

The results of a drug trial published in the New England Journal of Medicine found that 18 rectal cancer patients are now completely free of the disease.

The handful of patients were part of a study conducted at the Memorial Sloan Kettering Cancer Center (MSKCC) in Manhattan and resulted in a success rate of 100 percent. Each patient was under the age of 50.

“I believe this is the first time this has happened in the history of cancer,” Dr. Luis A. Diaz Jr, the author of the paper, told The New York Times.

The drug used in the study is called dostarlimab and was designed to retrain the body’s autoimmune system so it will attack certain tumors and mutations, which each patient in the trial possessed. All had been told their options were chemotherapy, radiation, and in some cases, complex surgery, but at the conclusion of the trial they were all relieved to find out they no longer needed any of those treatments, at least for now.


(Video: MSKCC/YouTube)

“There were a lot of happy tears,” Dr. Andrea Cercek, an oncologist at MSKCC, told the outlet.

Participant Sascha Roth remembered scrambling to pack in preparation to temporarily relocate from Washington, D.C. to New York where she would undergo weeks of radiation therapy, but a phone call from oncologist Cercek changed her plans and possibly her life.

“Dr. Cercek told me a team of doctors examined my tests,” recalled Sascha. “And since they couldn’t find any signs of cancer, Dr. Cercek said there was no reason to make me endure radiation therapy.”

“It’s incredibly rewarding,” says Dr. Cercek, “to get these happy tears and happy emails from the patients in this study who finish treatment and realize, ‘Oh my God, I get to keep all my normal body functions that I feared I might lose to radiation or surgery.'”

The medication was administered every three weeks for six months at a cost of around $11,000 per dose.

Cercek’s co-investigator at Memorial Sloan Kettering Cancer Center, Dr. Diaz said “Immunotherapy has proven successful in treating a subset of patients with colon and rectal cancer that has metastasized, meaning spread to other tissues.”

“An MMRd tumor develops a defect in its ability to repair certain types of mutations that occur in cells. When those mutations accumulate in the tumor, they stimulate the immune system, which attacks the mutation-ridden cancer cells,” said Diaz.

“The immunotherapy shrank the tumors much faster than I expected,” Cercek said. “My research nurse Jenna Sinopoli would tell me, ‘The patient has only received one treatment and already they’re not bleeding anymore and their terrible pain has gone away.’”

Cercek recalls, “Patients came to my office after just two or three treatments and said, ‘This is incredible. I feel normal again.’”

“One young man and his family just sat in stunned silence when I told them his cancer had disappeared,” recalled Cercek. “Then they thanked us over and over.” She continued, “A young woman looked at the screen during an examination and asked, ‘Where is the tumor?’ ‘It’s gone,’ we told her.”

Cercek concluded, “The most exciting part of this is that every single one of our patients has only needed immunotherapy. We haven’t radiated anybody, and we haven’t put anybody through surgery.” She added, “They have preserved normal bowel function, bladder function, sexual function, fertility. Women have their uterus and ovaries. It’s remarkable.”

In an editorial that accompanied the study, Dr. Hanna K. Sanoff of the University of North Carolina’s Lineberger Comprehensive Cancer Center described the results as “small but compelling.”

“Very little is known about the duration of time needed to find out whether a clinical complete response to dostarlimab equates to cure,” Sanoff wrote.

Nevertheless, the results seem promising for a wider array of patients as each involved in the trial has remained cancer-free, the earliest patients in the study for two years so far.

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11 thoughts on “All cancer patients test free of disease after going through ‘compelling’ new immunotherapy treatment

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  3. Treating cancer patients effectively by building the immune system is not new – in homeopathic medecine. They have simply found a way for the pharmaceutical companies to profit from it.

  4. ‘… handful of patients…’
    There must be a reason that the numbers were not mentioned.
    Is this 100% of two people?
    This article sounds like a promotion piece.

    1. First paragraph says 18 patients.

      The results of a drug trial published in the New England Journal of Medicine found that 18 rectal cancer patients are now completely free of the disease.

  5. This is truly a game changer. Now….don’t take three years of testing before the public can be saved. Give patients that have rectal cancer, the opportunity to make their own decision to try it now if they wish. I’m sure they will sign off any way you want.

  6. Shove the treatment up your ass if it requires the death jab ! Shut Sloan Kettering Down ! Everyone That I know went to them for help died. THEY SUCK BIG TIME !

    1. Was that 1 or 3 people that you know? Why deny other patients a chance to recover just because YOUR friends had a bad experience. NOT EVERYBODY gets cured of cancer, but many DO!!!

  7. Very expensive, but sounds like this could be a major breakthrough. I’m hopeful that the individuals remain cancer free for the rest of their lives.

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